Valerian Oil


Valerian Oil - Directory & Reference Resources

Valerian (herb)-From Wikipedia, the free encyclopedia

Valerian (plant)

Scientific classification

Kingdom: Plantae

Division: Magnoliophyta

Class: Magnoliopsida

Order: Dipsacales

Family: Valerianaceae

Genus: Valeriana

Species: V. officinalis

Binomial name

Valeriana officinalis

L. & Maillefer

Valerian (Valeriana officinalis, Valerianaceae) is a hardy perennial flowering plant, with heads of sweetly scented pink or white flowers. This "sweet" smell is quite overpowering when the flower is placed into a vase. The flowers are in bloom from June to September.

Native to Europe and parts of Asia, Valerian has been introduced into North America. It is consumed as food by the larvae of some Lepidoptera (butterfly and moth) species including Grey Pug.

Other names used for this plant include garden valerian (to distinguish it from other Valeriana species), garden heliotrope (although not related to Heliotropium) and all-heal.

Valerian, in Pharmacology and Phytoterapic Medicine, is the name of an herb or dietary supplement prepared from roots of the plant, which, after maceration, trituration, dehydration processes, are conveniently packaged, usually into capsules, that may be utilized for certain effects including sedation and anxiolytic effect.

Contents

1 Etymology

2 Biochemical composition

3 Mechanism of Action

4 Preparation

5 Medicinal use

6 Oral forms, usage and adverse effects

6.1 Oral forms

6.2 Usage

6.3 Adverse effects

7 Effect on Cats and Rats

8 Notes

9 See also

10 External links

 Etymology

The name Valerian comes from the Latin word valere, meaning "to be strong or healthy", generally thought to refer to its medicinal use, though many references suggest that it also refers to the strong odor.

 Biochemical composition

The biochemical active components of valerian extract are:

Alkaloids: actinidine, catinine, isovaleramide, valerianine and valerine;

Gama Aminobutiric acid (GABA), neurotransmitter connected to the sedative plant effects;

Valeric acid;

Valepotriates, esters non-glicosidic, firstly acevaltrate, isovaltrate and valtrate.

Volatile oil containing active sesquiterpenes (acetoxivalerenic acid, valerenic acid);

 Mechanism of Action

Due to valerian's historical use as a sedative, anti-convulsant, migraine treatment and pain reliever, most basic science research has been directed at the interaction of valerian constituents with the GABA neurotransmitter receptor system. These studies remain inconclusive and all require independent replication. The mechanism of action of valerian in general, as a mild sedative in particular, remains unknown. Valerian extracts appear to have some affinity for the GABAA (benzodiazepine) receptor,[1][2] but this activity does not appear to be mediated by valerenic acid, but rather by the relatively high content of γ-aminobutyric acid (GABA) itself.

 Preparation

Valeriana officinalisThe chief constituent of Valerian is a yellowish-green to brownish-yellow oil which is present in the dried root varying from 0.5 to 2 per cent though an average yield rarely exceeds 0.8 per cent. This variation in quantity is partly explained by location: a dry, stony soil, yielding a root richer in oil than one that is moist and fertile. [3] The volatile oils that form the active ingredient are extremely pungent, somewhat reminiscent of well-matured cheese or wet dog. Valerian tea should not be prepared with boiling water, as this may drive off the lighter oils.

 Medicinal use

Valerian is used for insomnia and other disorders.[4] [5] [6]

In the United States Valerian is sold as a nutritional supplement. Therapeutic use has increased as dietary supplements have gained in popularity, especially after the Dietary Supplement Health and Education Act was passed in 1999. This law allowed the distribution of many agents as over-the-counter supplements, and therefore allowed them to bypass the regulatory requirements of the Food and Drug Administration (FDA).

Valerian is used against sleeping disorders, restlessness and anxiety. Valerian seems only to work when taken over longer periods (several weeks). Some studies have demonstrated that valerian extracts interact with the GABA and benzodiazepine receptors. Valerian is also used traditionally to treat gastrointestinal pain and spastic colitis. Long term safety studies are missing. As valepotriates may be potential mutagens, valerian should only be used after consultation with a physician.

Valerian medication is sometimes recommended as first line when benefit-risk relation requires so. Valerian is often indicated as transition medication during discontinuation processes involving bromazepan, clonazepam and diazepam, among others.

Valerian has uses in herbal medicine as a sedative. The main current use of valerian is as a remedy for insomnia, with a recent meta-analysis providing some evidence of effectiveness.[7] It has been recommended for epilepsy but that is not supported by research. Large doses are known to cause withdrawal symptoms when stopped, as it, as well as most all sleep aids, may result in dependency. .[4]

While shown to be an effective remedy for the reduction of anxiety, it has also been reported to cause headaches and night terrors in some individuals. This is due to the fact that some people lack a digestive conversion property necessary to effectively break down Valerian. In these individuals, Valerian can cause agitation.[8] One study found that valerian tends to sedate the agitated person and stimulate the fatigued person, bringing about a balancing effect on the system.[9]

 Oral forms, usage and adverse effects

 Oral forms

Oral forms are available in both standardized and unstandardized forms. Standarized products may be preferable considering the wide variation of the chemicals in the dried root, as noted above. When standarized it is done so as a percentage of valerenic acid or valeric acid. Physician Formulas makes a 300 mg capsule standardized to 0.8 % valerenic acid (2.4mg).[10] Nature's Sunshine Time-Release Valerian tablet contains 500 mg of valerian root extract standardized to 0.8 % valerenic acid (4mg).[11] Nature Made makes a 400mg capsule standardized to only 0.28 % valerenic acid (0.56mg).[12] Nutraceutical makes two 50mg capsules under the names Solaray and Thompson standardized to 0.8 % valeric acid (0.4mg).[13]

 Usage

Dosage is difficult to determine due to the lack of standardization and variability in available forms.

 Adverse effects

Few adverse events attributable to valerian have been reported.[4]

 Effect on Cats and Rats

An unusual feature of valerian is that the dried root affects the domestic cat in a similar way as that of catnip. If valerian root is left in a place to which cats have access, they will roll in it, salivate onto it and eat it. [3] Burmese cats are attracted to the dried herb and will deliberately destroy containers to obtain it. However, some cats will not go near valerian root.[citation needed]

Valerian's effect on cats is featured as a clue in two works by Agatha Christie.[citation needed]

Valerian is also very attractive to rats, so much so that it has been used to bait traps. Some versions of the legend of the Pied Piper of Hamelin have him using valerian, as well as his pipes, to attract the rats. [3]

 Notes

^ Holzl J, Godau P. (1989). "Receptor binding studies with Valeriana officinalis on the benzodiazepine receptor.". Planta Medica 55. 

^ Mennini T, Bernasconi P, et al. (1993). "In vitro study in the interaction of extracts and pure compounds from Valerian officinalis roots with GABA, benzodiazepine and barbiturate receptors". Fitoterapia 64: 291-300. 

^ a b c Valerian. botanical.com. Retrieved on 2007-04-15.

^ a b c Questions and Answers About Valerian for Insomnia and Other Sleep Disorders. Office of Dietary Supplements • National Institutes of Health (4/13/2006). Retrieved on 2007-04-11.

^ Valerian. American Family Physician (4/13/2006). Retrieved on 2007-04-12.

^ Valerian (Valeriana officinalis L.). Medline Plus (10/1/2006). Retrieved on 2007-04-12.

^ ncbi.nlm.nih.gov

^ herbaleducator.com

^ [1]

^ Valerian Root Extract 300 mg. physicianformulas.com. Retrieved on 2007-04-11.

^ VALERIAN ROOT EXTRACT TIME RELEASE. naturessunshine.com. Retrieved on 2007-04-11.

^ Valerian Root 400mg. naturemade.com. Retrieved on 2007-04-11.

^ Valerian Root Extract 50mg. nutraceutical.com. Retrieved on 2007-04-11.

 See also

Anxiolytic

Nepeta

Valine

Sedative

Valeric acid

Valeriana

Sweet Valerian

Tisane

Valerian

Valerianaceae

Insomnia

Red Valerian

Spikenard

ATC code N05

Valeriana

Köhler's Medicinal Plants

Anxiety

Herbalism

Special Herbs, Vols. 4, 5 & 6

Special Herbs, Vols. 5 & 6

Orvietan

Valerian Oil

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